Updated for 2025! Must-Buy Items from Japanese Drugstores – Popular Picks You Shouldn’t Miss
With 2024 behind us, it’s time to welcome 2025 with an updated list of must-buy items from Japanese drugstores. Whether you’re shopping for yourself or picking up souvenirs, these products—both long-time bestsellers and new trending items—are highly recommended by the Payke editorial team. Thanks to the currently weak yen, now is the perfect time to grab these popular finds while visiting Japan!
And now, we’re holding a limited-time scan event for the products featured in this article!
Click here for event details
If you spot any of these featured items in stores during your trip to Japan, don’t miss the chance to pick them up and try scanning the barcode with the Payke app♪
Gyutto Hair Mask
If you’re dealing with frizzy or dry hair caused by humidity or harsh weather, Gyutto Hair Mask is an excellent treatment that helps keep your hair in place and looking healthy.
This mask penetrates deep into the hair shaft while also coating the surface to repair and smoothen damaged strands. Easy to use after shampooing, it’s especially ideal for rainy or dry days.
Recommended for those worried about their hairstyle losing shape throughout the day.
Product Information
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Product Name: Gyutto / ギュット（R ヘアマスクa）
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Volume: 200g
THE LYPO Vitamin C Deep Capsules
You might have seen beauty bloggers raving about THE LYPO Vitamin C Deep Capsules last year. These capsules, containing Liposomal Vitamin C and hyaluronic acid, are popular in Japan for boosting skin health from within.
Take two capsules daily for a simple and effective addition to your wellness routine.
Product Information
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Product Name: THE LYPO Vitamin C Deep Capsules / ザリポ ビタミンCディープカプセル
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Volume: 60 capsules
Laundrin Perfumed Fabric Mist
Source : Laundrin official website
Worried about lingering odors after meals or social events? Don’t miss out on Laundrin Perfumed Fabric Mist when shopping in Japan.
These fabric sprays come in a variety of elegant and natural scents, effectively neutralizing unpleasant odors. A top pick is the Bergamot & Cedar fragrance, known for its refreshing and calming aroma—perfect for both home and office use.
Product Information
■ Product Name: Laundrin Perfumed Fabric Mist / ファブリックミスト シリーズ
■Volume: 300mL
Mentholatum Acnes 25 Medical Mist
Struggling with acne on hard-to-reach areas like your back or chest? Try Mentholatum Acnes 25 Medical Mist—a spray formulated to treat breakouts with ease.
It contains antibacterial agents and salicylic acid to clean pores and promote skin recovery, all with a light, colorless formula and a subtle scent.
Product Information
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Product Name: Mentholatum Acnes 25 Medical Mist / メンソレータムアクネス25メディカルミスト
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Volume: 100mL
Muhi S2a Liquid Anti-Itch Lotion
Muhi S2a is a lightweight liquid treatment for itchiness and inflammation, containing diphenhydramine hydrochloride and dexamethasone acetate. The cooling, herbal-scented formula is easy to apply with a sponge applicator—no mess and travel-friendly.
Product Information
■Product Name: Muhi S2a Liquid Anti-Itch Lotion / 液体ムヒ S2a
■Volume: 50mL
V Rohto Premium – Eye Drops
If you’re looking for high-quality eye drops for yourself or someone else, consider V Rohto Premium Blue Diamond and Red Diamond.
Blue Diamond: Ideal for relieving digital eye fatigue, perfect for modern lifestyles.
Red Diamond: Popular among older adults for its targeted comfort and relief.
Product Information
■Product Name:
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V Rohto Premium Blue Diamond / Vロートプレミアム
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V Rohto Premium Red Diamond / Vロートアクティブプレミアム
■Volume: 15mL
Product details here (Blue Diamond)
Product details here (Red Diamond)
ROHTO Lycee Eyedrops
Adored by Japanese office workers for its cute pink packaging and gentle formula, ROHTO Lycee eye drops help soothe dry, tired, and red eyes. The blend of nourishing ingredients makes it an excellent choice for first-time users.
Product Information
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Product Name: ROHTO Lycee Eyedrops / リセ
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Volume: 8mL
SKIN AQUA Tone Up UV Fleeting Blue
The popular Tone Up UV sunscreen series from SKIN AQUA returns in 2025 with a new shade: Fleeting Blue. This base sunscreen brightens the skin naturally while protecting it with hyaluronic acid and vitamin C.
A must-have for anyone seeking radiant, dewy skin.
Product Information
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Product Name: SKIN AQUA Tone Up UV Fleeting Blue / スキンアクアトーンアップUVはかなげブルー
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Volume: 80g
SKIN AQUA Hyaluronic Serum UV
Launched in early 2025, SKIN AQUA Hyaluronic Serum UV is a highly anticipated sunscreen serum. It offers the highest hyaluronic acid concentration in the brand’s series, providing intense moisture with a lightweight, alcohol-free texture.
Doubles as a makeup base—perfect for achieving luminous skin.
Product Information
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Product Name: SKIN AQUA Hyaluronic Serum UV / スキンアクアヒアルロンセラムUV
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Volume: 70g
Calamee Calamine Nosebum Lotion
As the weather heats up, oily skin and makeup melt become common concerns. Calamee Calamine Nosebum Lotion helps manage excess sebum while refreshing and prepping the skin.
Its blend of calamine and six botanical extracts (like aloe vera and centella asiatica) helps tighten pores and balance the skin—great as a daily skincare or makeup primer.
Product Information
■Product Name: Calamee Calamine Nosebum Lotion / カラミンノーセバムローション
■Volume: 180mL
Calamee Calamine Nosebum Gel
For long-lasting matte skin, try Calamee Calamine Nosebum Gel—a lightweight gel for oily skin with calamine powder to absorb excess sebum and blur imperfections with a soft-focus effect.
Formulated with the same six plant extracts, it keeps skin hydrated, smooth, and makeup-ready all day.
Product Information
■ Product Name: Calamee Calamine Nosebum Gel / カラミンノーセバムジェル
■ Volume: 70g
Calamee Make Keep Square Pack
No time in the morning? Calamee Makeup Square Pack offers quick and effective morning skincare with 50 pre-soaked cotton sheet masks per box. It hydrates, controls oil, and helps makeup last longer.
Contains calamine and plant extracts for balanced, smooth skin—ideal before makeup application.
Product Information
■ Product Name: Calamee Makeup Square Pack / カラミーメイクキープスクエアパック
■ Volume: 50 sheets
Final Tip: Make the Most of Your Shopping Trip
Japanese drugstores are packed with so many options that shopping can feel overwhelming—especially in busy tourist areas. Before your visit, consider preparing a list of items (including Japanese names) to make your shopping more efficient. Also, by downloading discount coupons for various drugstores prepared by Payke in advance, you can enjoy even greater savings while shopping. Shop smart and head home with a sense of satisfaction!